The Human SRCAP Chromatin Remodeling Complex Promotes DNA-End Resection
نویسندگان
چکیده
منابع مشابه
The Human SRCAP Chromatin Remodeling Complex Promotes DNA-End Resection
BACKGROUND Repair of DNA double-strand breaks (DSBs) by homologous recombination requires 5'-3' resection of the DSB ends. In vertebrates, DSB resection is initiated by the collaborative action of CtIP and the MRE11-RAD50-NBS1 (MRN) complex. However, how this process occurs within the context of chromatin is still not well understood. RESULTS Here we identify the human SRCAP chromatin remodel...
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ژورنال
عنوان ژورنال: Current Biology
سال: 2014
ISSN: 0960-9822
DOI: 10.1016/j.cub.2014.07.081